GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2243480 | 1 | rs6958420 | chr7:65751171 | CCT6P1 | chr7:65216092-65228661:+ | -0.44 | -6.92 | 1.49E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6958420 | chr7:65751171 | CRCP | chr7:65579805-65619551:+ | 0.29 | 4.43 | 1.19E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6958420 | chr7:65751171 | LOC493754 | chr7:65993446-66057363:- | -0.3 | -3.38 | 0.000785 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6958420 | chr7:65751171 | RABGEF1 | chr7:66093890-66276446:+ | -0.6 | -7.44 | 4.68E-13 | Diabetic kidney disease |
| THCA | cis | rs875971 | 1 | rs6958484 | chr7:65599446 | ASL | chr7:65540776-65558321:+ | 0.16 | 4.27 | 2.34E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6958484 | chr7:65599446 | GUSB | chr7:65425675-65447246:- | -0.27 | -5.31 | 1.66E-7 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6958484 | chr7:65599446 | LOC729156 | chr7:66274980-66309813:- | -0.16 | -3.49 | 0.000535 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6958484 | chr7:65599446 | RABGEF1 | chr7:66093890-66276446:+ | -0.66 | -14.15 | 3.18E-38 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs6958520 | chr7:66151453 | GUSB | chr7:65425675-65447246:- | 0.33 | 6.8 | 3.22E-11 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs6958520 | chr7:66151453 | RABGEF1 | chr7:66093890-66276446:+ | 0.51 | 10.49 | 2.65E-23 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs6958520 | chr7:66151453 | TYW1 | chr7:66461817-66704496:+ | 0.18 | 3.93 | 9.79E-5 | Aortic root size |
| THCA | cis | rs4730250 | 1 | rs6958969 | chr7:107197755 | DLD | chr7:107531586-107561642:+ | 0.14 | 3.49 | 0.000521 | Osteoarthritis |
| THCA | cis | rs2243480 | 1 | rs6959002 | chr7:65650496 | CCT6P1 | chr7:65216092-65228661:+ | -0.42 | -6.7 | 5.9E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6959002 | chr7:65650496 | CRCP | chr7:65579805-65619551:+ | 0.3 | 4.63 | 4.66E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6959002 | chr7:65650496 | LOC493754 | chr7:65993446-66057363:- | -0.29 | -3.36 | 0.000833 | Diabetic kidney disease |